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Lithium vs Quetiapine for Depression (LQD Study)

We aim to compare the effectiveness of quetiapine and lithium in people with treatment resistant depression.

The study is aimed at people who are struggling with depression, who are currently taking antidepressants that don't seem to be working for them. 

After checking for eligibility, participants will be randomised to quetiapine or lithium, which they will take alongside their current antidepressant for as long as is right for them. The study would want to follow participants up for 12 months, and there will be 4 or 5 meetings throughout the year with the researcher to assess how things are going.


We are looking for:

Inclusion criteria:

  • Diagnosis of major depression
  • Not responded to (or relapsed whilst taking) two antidepressants in the current episode
  • On current antidepressant for at least five weeks
  • Aged 18 or over

Exclusion Criteria:

  • Bipolar disorder
  • Current psychosis
  • Pregnant or lactating
  • Use of lithium or quetiapine during current episode
  • Known contraindication to either quetiapine or lithium


  • South East
  • London


We cover travel expenses within London.

Contact information:

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